Cleanroom Monitoring Planning Guide

Monitoring design follows the classification you have to demonstrate. Fix the class and the standard first; sample point count, particle channels and record keeping all follow from it.

Selection Requirements to Establish

Work through what you can. Anything still undecided is exactly what a conversation with our engineers is for.

01Classification and standard

  • ISO 14644-1 class, or the GMP grade being worked to
  • Whether classification is at rest, in operation, or both
  • Room area and volume, which set the minimum number of sample points
  • Particle sizes that must be reported for that class
  • Recovery and pressure-cascade tests within scope

02Measurement and instruments

  • Portable counter for periodic classification, or fixed sensors for continuous monitoring
  • Sample flow rate — 28.3 l/min shortens the sample time a class demands
  • Number of monitoring locations and the sampling schedule
  • Isokinetic probes, manifolds or sequencing where used
  • Additional parameters: temperature, humidity, differential pressure, airflow

03Data, alarms and validation

  • Alarm thresholds and how alarms are escalated
  • Record retention, audit trail and electronic signature requirements
  • Interface to the building management or monitoring system
  • Reports required for qualification (IQ, OQ, PQ)
  • Calibration and requalification intervals